Lipopolysaccharide Increases Plasma Levels of Corticotropin-Releasing Hormone in Rats
نویسندگان
چکیده
منابع مشابه
Antalarmin blockade of corticotropin releasing hormone-induced hypertension in rats.
Central administration of CRH results in endocrinological, cardiovascular, and behavioral effects that suggest stress or anxiety. Among these is a marked pressor response. Parenteral administration of CRH, however, results in hypotension. We used parenteral administration of antalarmin, a novel, small molecule CRH1 receptor antagonist, and alpha-helical CRH(9-41), a peptidic CRHR1/CRHR2 antagon...
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Corticotropin-releasing hormone (CRH), also known as corticotropin-releasing factor, is a highly conserved peptide hormone comprising 41 amino acid residues. Its name derives from its role in the anterior pituitary, where it mediates the release of corticotropin (ACTH) leading to the release of adrenocortical steroids. CRH is the major hypothalamic activator of the hypothalamic–pituitary– adren...
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Corticotropin-releasing hormone (CRH) and related peptides (urocortins, sauvagine, urotensin) play a central role in the co-ordination of autonomic, behavioural, cardiovascular, immune and endocrine responses to stressful stimuli. Their actions are mediated through activation of two types of G-protein-coupled receptors encoded by separate genes. In this review we focus on the diverse structural...
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We investigated whether acute stressors regulate functional properties of the hippocampal mineralocorticoid receptor (MR), which acts inhibitory on hypothalamic-pituitary-adrenocortical activity. Exposure of rats to forced swimming or novelty evoked a significant rise in density of MR immunoreactivity in all hippocampal subfields after 24 hr, whereas exposure to a cold environment was ineffecti...
متن کاملCorticotropin-releasing hormone in nonhuman primates.
Understanding the many roles that corticotropin-releasing hormone (CRH) plays in facilitating the ordinary and extraordinary events that an individual faces during a lifetime is a complex task, and yet this knowledge is fundamental to understanding our own behaviour and physiology. During the past 25 years, the study of CRH in nonhuman primates, our closest genetic relatives, has grown rapidly....
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ژورنال
عنوان ژورنال: Neuroendocrinology
سال: 2011
ISSN: 1423-0194,0028-3835
DOI: 10.1159/000322590